Study: High CBD levels in cannabis can counteract negative side-effects of THC


A new study suggests cannabis with higher amounts of cannabidiol (CBD) could counteract negative effects associated with tetrahydrocannabinol (THC).

Indiana University researchers conducted an experiment where they injected mice with measured doses of THC and CBD to gauge their reactions. When pure THC was administered, the mice showed anxiety and memory impairment. However, when equal doses of THC were given, the mice did not experience any of the previous side effects.

Cannabidiol (CBD) is a compound within the cannabis plant known for its medical properties and lack of psychoactive effects on the user. Tetrahydrocannabinol (THC) is another compound found in the plant which produces a “high” for the user.

Researchers examined the effects on both adolescent and adult mice which were split into five different groups. One group received THC only, one received CBD only and one group received equal amounts of both compounds. The other two groups received a placebo or no treatment at all.

The research team also found the adolescent mice given THC showed negative symptoms six weeks after treatment, but both adolescent and adult mice injected with both compounds showed no symptoms at all.

This new information deviated from a previous short-term study conducted in 2013 which did not use lab mice or any subjects outside of previously conducted studies.  The 2013 study could not conclude if CBD cancelled out the negative effects of THC due to the lack of information and long-term research on live subjects. The previous studies examined were conducted before the advent of legal cannabis, which doesn’t take the regulated cannabis markets into consideration.